Cdk-counteracting phosphatases unlock mitotic exit
نویسندگان
چکیده
منابع مشابه
Protein Phosphatases Drive Mitotic Exit
Mitosis is the final stage of the cell cycle that results in the formation of two independent daughter cells with an equal and identical complement of chromosomes (Figure 1). This requires a complex series of events such as nuclear envelope breakdown, spindle formation, equal chromosome segregation, packaging of chromosomes into daughter nuclei and constriction of the plasma membrane at the cel...
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The feedback we have now received, I am afraid to say, provides insufficient support for us to consider this study further for publication. While referee 1 is cautiously leaning to a more favorably recommendation, both referees 2 and 3 indicate major reservations. These are based on a number of specific concerns with the experimental evidence and its presentation, which I will not repeat in det...
متن کاملThe Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.
Polarisation of the actin cytoskeleton must cease during cytokinesis, to support efficient assembly and contraction of the actomyosin ring at the site of cell division, but the underlying mechanisms are still understood poorly in most species. In budding yeast, the Mitotic Exit Network (MEN) releases Cdc14 phosphatase from the nucleolus during anaphase, leading to the inactivation of mitotic fo...
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Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylation, but the dynamic regulation of Greatwall activity and the phosphatases that control Greatwall kinase and its substrates are poorly understood. To...
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Budding yeast protein phosphatase Cdc14 is sequestered in the nucleolus in an inactive state during interphase by the anchor protein Net1. Upon entry into anaphase, the Cdc14 early anaphase release (FEAR) network initiates dispersal of active Cdc14 throughout the cell. We report that the FEARnetwork promotes phosphorylation of Net1 by cyclin-dependent kinase (Cdk) complexed with cyclin B1 or cy...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2008
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2008.09.003